Efficiency for early treatment of Class III malocclusions remains controversial. Resulting in unpredictable relapse, some clinicians are convinced early treatment often a waste of time and resources. However, others believe that early treatment in mixed dentition is beneficial to normalize the skeletal disharmony. The decision-making for proper treatment timing in individuals is complicated due to variability in growth potential and response to different treatment methodology. By illustrating successfully treated cases, the current presentation somewhat discuss several elements that may contribute to the good response of early treatment of Class III malocclusion.