The spheno-occipital synchondrosis is an important growth center of the craniofacial skeleton. It is influential on the position of both the maxilla and mandible. During the postnatal period, endochondral ossification of the synchondrosis contributes largely to the expansion of the ossification centers and growth of the cranial base. Research for growth modification has shown that both the condyle and retromolar fossa will response to tensile mechanical stress, however, will the same applies to the synchondrosis? The presentation will attempt to touch on this exciting field.