Palatogenesis begin with the enlargement of the palatal shelves and bilateral outgrowth, then the palatal processes elevate and grow towards the midline. Thereafter, the bilateral palatal processes fuse with each other in the midline. Disruption at any step of the process results in the formation of a cleft palate. This presentation will review the recent findings on cellular and molecular mechanism underlying epithelial-mesenchymal interactions during palatal development.