Complex malocclusions are often characterised by significant shape, size and positional anomalies in three-dimensional space of the dento-alveolar and skeletal components. The planning of treatment and subsequent management of these malocclusions will require detailed evaluation of the extent of anatomic deviation, and the appropriate sequential treatment steps to achieve an optimal occlusion and outcome. Advanced computer technology such as digital models of the occlusion which is easily available to orthodontists can be harnessed to provide a visual step-by-step treatment planning of these malocclusions. This presentation aims to inform the audience with clinical examples that managing complex malocclusions can be approached with confidence through highly visual computer-aided simulations of treatment options. In addition, the certainty of a treatment outcome can be foreseen and determined with these patient-specific simulations.