The objective of this study was to compare smile attractiveness between different treatment protocols of Class II subdivision malocclusion (1, 3 and 4-premolar extraction protocols) and verify the esthetic influence of buccal and posterior corridors on smile attractiveness. The sample consisted of posed smile photographs obtained from 68 subjects, divided into 3 groups according to the treatment extraction protocol. Group 1, treated with 1 premolar extraction protocol included 20 subjects. Group 2, treated with 4 premolars extraction included 25 subjects. The 23 patients in group 3 were treated with 3 premolar extractions. The buccal and posterior corridors of each photograph were measured in proportion to smile width. To rate the posed smile photographs, panels of 70 orthodontists and 46 laypeople used a 10-point scale. Smile attractiveness and differences between the 3 groups and between the 2 panels of raters were subjected to Two-way ANOVA. To determine the relationship between rater’s gender and age and the esthetic scores Analysis of Covariance was used. Pearson correlation coefficients were calculated to determine the relationship of buccal and posterior corridors size to the esthetic score. The results showed that there were no significant differences in smile attractiveness scores between the 3 groups and between orthodontists and laypeople. Also rater’s gender and age did not influence the esthetic score. The buccal and posterior corridors size did not influence the esthetic score. Additionally, buccal and posterior corridors size did not differ between the groups.