Professor Wiltshire will elucidate the advances in bonding and adhesion of orthodontic brackets and provide a state-of-the-art overview of the newest and latest generations of adhesives and the impact of nanotechnology for those difficult and compromised bonding situations, such as bonding to fluorosed and hypoplastic enamel. Bonding to substrates like porcelain, composite and amalgam will also be addressed. An evidence-based overview of anticariogenicity, and the early detection of enamel decalcification around orthodontic attachments will be provided, together with those novel new technologies available for improved prevention, early detection and treatment of decalcification, expounding the beneficial roles of the biofilm, low-dose fluoride, calcium and phosphate and probiotics. Professor Wiltshire will also focus on up- to- date information on allergenicity in orthodontics and discuss bisphenol A safety in the orthodontic office.