Accelerated orthodontic tooth movement remains one of the most difficult and unsolved tasks in orthodontics, specially in adult patients. Although the self-ligating bracket system accelerates orthodontic tooth movement in some case reports, its overall and average performance is not promising. This could be due to the individual differences in alveolar bone metabolism or biology. The aims of this presentation are to screen the possible factors or biological predictors that affect or determine the individual differences in velocity of orthodontic tooth movement, and to explore the clinical feasibilities for accelerating orthodontic tooth movement based on the individual differences in bone biology.