Repair of Articular Cartilage Using DDM

  • Dr Ken Miyazawa, Department of Orthodontics School of Dentistry, Aichi-Gakuin University, Japan
  • Dr Keisuke Yagihashi, Department of Orthodontics School of Dentistry, Aichi-Gakuin University, Japan
  • Dr Atsushi Yasuda, Department of Orthodontics School of Dentistry, Aichi-Gakuin University, Japan
  • Prof Shigemi Goto, Department of Orthodontics School of Dentistry, Aichi-Gakuin University, Japan

Objective: In the present study, we demonstrate the capacity of Demineralized dentin Matrix (DDM) from extracted teeth for articular cartilage repair effect.
Materials and Methods: Full-thickness cartilage defects were created in the total of 66 trochlear grooves of 33 New Zealand White rabbits. Twenty two defects were filled with the DDM of 100mg (group I), 22 with DDM of 50mg (group II) and 22 were left empty (group III).The animals were killed 1, 3, 6 and 9 weeks after surgery, and the gross appearance of the defect sites was assessed. The harvested tissues were examined radiographically and histologically.
Results: Three weeks after implantation, Full-thickness cartilage defects in groupItended to be filled with more newly formed bone than the control group (group III). Six weeks after implantation, defects treated with the DDM of 100mg (group I) were filled with regenerated subchondral bone.
Conclusions: DDM is promising as a scaffold for articular cartilage repair.