Vertical control is the most important procedure during orthodontic treatment, especially in patient with high mandibular plane angle. We applied microscrew as anchorage for intrusion of molars in high mandibular angle cases. Our clinical study showed that the molars were intruded, and mandibular plane angle was reduced. The mandible rotated upward and forward, and patient's profile improved dramatically. The indication and effectiveness of microscrew for intrusion of molars were discussed.